There are many people with serious personality problems, people who go after the vices and have sought different institutions to change their ways of being in society and simply have not been able. Their relatives have searched for the best specialists and lost fortunes in the attempt and there has been no change whatsoever.
They simply have not been able to change, however much they feel the desire to do so, they simply feel weak and manipulated by their sinful desires. I know that each of us has a story to tell of how Christ has intervened in our lives, to the point that He has transformed us in such a way that we are no longer the same people as before.
There is a passage in the Bible that talks about this: